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• Long-term metformin use is a recognised cause of low B12: the MHRA now lists it as a common side effect, affecting up to one in ten users

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All these points support the further target’s (i.e., smooth muscle, i.e., pupil [86], or lower esophageal sphincter and pyloric sphincter [92] and urethral sphincter [100], and blood vessel [122]) sensitivity to NOS-blockade or NOS-over activity that can be distinctive